Greensporone A, a Fungal Secondary Metabolite Suppressed Constitutively Activated AKT via ROS Generation and Induced Apoptosis in Leukemic Cell Lines

Greensporone A, a Fungal Secondary Metabolite Suppressed Constitutively Activated AKT via ROS Generation and Induced Apoptosis in Leukemic Cell Lines

<div><p>Greensporone A is a fungal secondary metabolite that has exhibited potential in vitro for anti-proliferative activity in vitro. We studied the anticancer activity of greensporone A in a panel of leukemic cell lines. Greensporone A-mediated inhibition of proliferation is found to...

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Bibliographic Details
Main Author: Kirti Prabhu (3520064) (author)
Other Authors: Kodappully Siveen (3520073) (author), Shilpa Kuttikrishnan (3520079) (author), Anh Jochebeth (17017782) (author), Tayyiba Ali (18134116) (author), Noor Elareer (18134119) (author), Ahmad Iskandarani (3520067) (author), Abdul Quaiyoom Khan (283343) (author), Maysaloun Merhi (4246147) (author), Said Dermime (79420) (author), Tamam El-Elimat (694398) (author), Nicholas Oberlies (18134122) (author), Feras Alali (1562164) (author), Martin Steinhoff (5340194) (author), Shahab Uddin (154400) (author)
Published: 2019
Subjects:
Biological sciences
Biochemistry and cell biology
AKT
apoptosis
cIAP
greensporone A
imatinib
reactive oxygen species
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