Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

<div><p>Rho family proteins are prenylated by geranylgeranyltransferase type I (GGTase-I), which normally target proteins to membranes for GTP-loading. However, conditional deletion of GGTase-I in mouse macrophages increases GTP-loading of Rho proteins, leading to enhanced inflammatory r...

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Bibliographic Details
Main Author: Murali K. Akula (9389280) (author)
Other Authors: Mohamed X. Ibrahim (18614953) (author), Emil G. Ivarsson (18614956) (author), Omar M. Khan (17807774) (author), Israiel T. Kumar (18614959) (author), Malin Erlandsson (11926641) (author), Christin Karlsson (18614962) (author), Xiufeng Xu (428514) (author), Mikael Brisslert (257843) (author), Cord Brakebusch (264269) (author), Donghai Wang (242685) (author), Maria Bokarewa (11496) (author), Volkan I. Sayin (14590256) (author), Martin O. Bergo (9389283) (author)
Published: 2019
Subjects:
Biological sciences
Biochemistry and cell biology
Rho family proteins
Geranylgeranyltransferase type I (GGTase-I)
Prenylation
GTP-loading
Inflammatory responses
Rheumatoid arthritis
Rac1
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