Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-world studies

Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-world studies

<p>This systematic review aims to summarise the clinical outcomes of l-glutamine, crizanlizumab, and voxelotor in the treatment of sickle cell disease (SCD) based on clinical trials and real-world data and to identify any gaps in the observations. The review identified 97 studies reporting dat...

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Bibliographic Details
Main Author: Mohamed Yassin (4166515) (author)
Other Authors: Caterina Minniti (21189398) (author), Nirmish Shah (6672725) (author), Salam Alkindi (11601856) (author), Fateen Ata (12217764) (author), Mohammed Qari (21189401) (author), Abdullah Al Zayed (21189404) (author), Jaffer Altooq (18186850) (author), Mona Al Rasheed (12040519) (author), Maria Domenica Capellini (21189407) (author)
Published: 2025
Subjects:
Biomedical and clinical sciences
Cardiovascular medicine and haematology
Clinical sciences
Pharmacology and pharmaceutical sciences
Sickle cell diseasel-glutamine
Crizanlizumab
Voxelotor, real-world studies
Clinical trials
Vaso-occlusive crisis
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