Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-world studies

<p>This systematic review aims to summarise the clinical outcomes of l-glutamine, crizanlizumab, and voxelotor in the treatment of sickle cell disease (SCD) based on clinical trials and real-world data and to identify any gaps in the observations. The review identified 97 studies reporting dat...

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Bibliographic Details
Main Author:	Mohamed Yassin (4166515) (author)
Other Authors:	Caterina Minniti (21189398) (author), Nirmish Shah (6672725) (author), Salam Alkindi (11601856) (author), Fateen Ata (12217764) (author), Mohammed Qari (21189401) (author), Abdullah Al Zayed (21189404) (author), Jaffer Altooq (18186850) (author), Mona Al Rasheed (12040519) (author), Maria Domenica Capellini (21189407) (author)
Published:	2025
Subjects:	Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Pharmacology and pharmaceutical sciences Sickle cell diseasel-glutamine Crizanlizumab Voxelotor, real-world studies Clinical trials Vaso-occlusive crisis
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Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-world studies

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