Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling

Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling

<p dir="ltr">Sanguinarine (SNG), a benzophenanthridine alkaloid, has displayed various anticancer abilities in several vivo and <i>in vitro</i> studies. However, the anticancer potential of SNG is yet to be established in multiple myeloma (MM), a mostly incurable malignan...

وصف كامل

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Sabah Akhtar (5809925) (author)
مؤلفون آخرون:	Iman W. Achkar (4246141) (author), Kodappully S. Siveen (4246150) (author), Shilpa Kuttikrishnan (3520079) (author), Kirti S. Prabhu (4246144) (author), Abdul Q. Khan (14153247) (author), Eiman I. Ahmed (6595514) (author), Fairooz Sahir (6595517) (author), Jayakumar Jerobin (6595520) (author), Afsheen Raza (492657) (author), Maysaloun Merhi (4246147) (author), Hesham M. Elsabah (6595523) (author), Ruba Taha (6595526) (author), Halima El Omri (6595529) (author), Hatem Zayed (835448) (author), Said Dermime (79420) (author), Martin Steinhoff (5340194) (author), Shahab Uddin (154400) (author)
منشور في:	2019
الموضوعات:	Biomedical and clinical sciences Oncology and carcinogenesis apoptosis caspases STAT3 sanguinarine multiple myeloma hematological malignancy
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

مواد مشابهة

Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway
حسب: Kirti.S. Prabhu (17191231)
منشور في: (2021)

Cytokine-Mediated Dysregulation of Signaling Pathways in the Pathogenesis of Multiple Myeloma
حسب: Sabah Akhtar (5809925)
منشور في: (2020)

Establishment of a clinical pharmacist-led multiple myeloma clinic with collaborative prescribing model at the national center for cancer care and research in Qatar
حسب: Rola Ghasoub (16555851)
منشور في: (2024)

Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway
حسب: Shilpa Kuttikrishnan (3520079)
منشور في: (2023)

Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy
حسب: Mahmoud Izadi (12899508)
منشور في: (2021)

Curcumin induces apoptosis via downregulation of SKP2 and induction of GADD45A/CDKN1A expression through generation of ROS in cutaneous T-cell lymphoma cells
حسب: Shilpa Kuttikrishnan (3520079)
منشور في: (2025)

The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities
حسب: Kalyani Patil (2679424)
منشور في: (2024)

Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1–mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma
حسب: Sarita Saraswati (7509626)
منشور في: (2019)

Ecthyma gangrenosum: a rare manifestation of Stenotrophomonas maltophilia infection in acute myelogenous leukemia patient
حسب: Gawahir A. Ali (14777260)
منشور في: (2021)

A Review of Artificial Intelligence Applications in Hematology Management: Current Practices and Future Prospects
حسب: Yousra El Alaoui (18427914)
منشور في: (2022)

Kefir inhibits proliferation and induces apoptosis of epithelial colorectal adenocarcinoma cells. (c2011)
حسب: Hayek, Stephanie E.
منشور في: (2011)

STAT3 promotes IFNγ/TNFα‐induced muscle wasting in an NF‐κB‐dependent and IL‐6‐independent manner
حسب: Jennifer F Ma (18629359)
منشور في: (2017)

Tunisian Artemisia campestris L.: a potential therapeutic agent against myeloma - phytochemical and pharmacological insights
حسب: Inès Limam (21393527)
منشور في: (2024)

Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments
حسب: Gunjan Dagar (9339276)
منشور في: (2023)

Dissecting bloodstream infections in febrile neutropenic patients with hematological malignancies, a decade-long single center retrospective observational study (2009–2019)
حسب: Halima El Omri (14778790)
منشور في: (2023)

Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation
حسب: Shilpa Kuttikrishnan (3520079)
منشور في: (2025)

Prediction of Multiple Clinical Complications in Cancer Patients to Ensure Hospital Preparedness and Improved Cancer Care
حسب: Regina Padmanabhan (14231606)
منشور في: (2022)

Nobiletin Inhibits CD36-Dependent Tumor Angiogenesis, Migration, Invasion, and Sphere Formation Through the Cd36/Stat3/Nf-Κb Signaling Axis
حسب: Nipin Sp (11639983)
منشور في: (2018)

<i>Haematococcus pluvialis</i> Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells
حسب: Nouralhuda Alateyah (21363215)
منشور في: (2022)

The experience of patients with hematological malignancy in their terminal stage: a phenomenological study from Jordan’s perspective
حسب: Mohammad M. Alnaeem (14778538)
منشور في: (2024)

Characteristics and comparisons of acute stroke in “recovered" to “active COVID-19 and “pre-pandemic” in Qatar database
حسب: Naveed Akhtar (14151642)
منشور في: (2022)

The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants
حسب: Ana Rio-Machin (19686124)
منشور في: (2020)

Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways
حسب: Hadeel, Kheraldine
منشور في: (2021)

Automatic White Blood Cell Differential Classification
حسب: Al-Muhairy, Juma A. Bin Darwish
منشور في: (2005)

Sternbergia Clusiana Bulb Ethanolic Extracts Induce Apoptosis in MCF-7 Breast Cancer Cells
حسب: Elias, Nazira
منشور في: (2022)

Malva pseudolavatera Leaf Extract Promotes ROS Induction Leading to Apoptosis in Acute Myeloid Leukemia Cells in Vitro
حسب: El Khoury, Marianne
منشور في: (2020)

Population based treatment strategy of H pylori in Qatar: Through clinical and demographic insights
حسب: Zohaib A.W. Khan (22051949)
منشور في: (2024)

Greensporone A, a Fungal Secondary Metabolite Suppressed Constitutively Activated AKT via ROS Generation and Induced Apoptosis in Leukemic Cell Lines
حسب: Kirti Prabhu (3520064)
منشور في: (2019)

<i>Asterarcys quadricellulare</i> (Chlorophyceae) protects H9c2 cardiomyoblasts from H<sub>2</sub>O<sub>2</sub>-induced oxidative stress
حسب: Imen Saadaoui (14159025)
منشور في: (2022)

COVID-19 Vaccination in Cancer Patients: A Review Article
حسب: Rana Mekkawi (18472390)
منشور في: (2022)

Biomonitoring of Toxic Effects of Pesticides in Occupationally Exposed Individuals
حسب: Arshad, Muhammad
منشور في: (2016)

Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomes
حسب: Hesham Elsabah (8984069)
منشور في: (2024)

Emerging therapies in multiple myeloma
حسب: El-Amm, Joelle
منشور في: (2015)

Calcium Entry through TRPV1: A Potential Target for the Regulation of Proliferation and Apoptosis in Cancerous and Healthy Cells
حسب: Kevin Zhai (18877843)
منشور في: (2020)

BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells
حسب: Ali Alhoshani (3720718)
منشور في: (2020)

Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways
حسب: Hadeel Kheraldine (14231609)
منشور في: (2021)

Transcriptomic Analyses of Myeloid-Derived Suppressor Cell Subsets in the Circulation of Colorectal Cancer Patients
حسب: Varun Sasidharan Nair (5396393)
منشور في: (2020)

Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions
حسب: Reem Khaled M.E. Alsayed (17563251)
منشور في: (2023)

Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back
حسب: Lenka Koklesova (18102994)
منشور في: (2020)

Beware of covert enemies: Candida orthopsilosis malignant otitis externa with base of the skull osteomyelitis, a case report and review of literature
حسب: Junais Koleri (17280586)
منشور في: (2021)