Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments

Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments

<div><p>Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune system's T-cells to recognize and attack tumor cells. T-cells are isolated from patients and mod...

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Main Author: Gunjan Dagar (9339276) (author)
Other Authors: Ashna Gupta (14150955) (author), Tariq Masoodi (8117702) (author), Sabah Nisar (12561961) (author), Maysaloun Merhi (4246147) (author), Sheema Hashem (14150961) (author), Ravi Chauhan (14150958) (author), Manisha Dagar (9339273) (author), Sameer Mirza (685921) (author), Puneet Bagga (4055866) (author), Rakesh Kumar (8432) (author), Ammira S. Al-Shabeeb Akil (15376391) (author), Muzafar A. Macha (11605200) (author), Mohammad Haris (564809) (author), Shahab Uddin (154400) (author), Mayank Singh (793077) (author), Ajaz A. Bhat (12984701) (author)
Published: 2023
Subjects:
Biological sciences
Biochemistry and cell biology
Genetics
CAR-T cell therapy
Immunotherapy
Tumor antigens
Antigen escape
Cytokine release syndrome
Hematological malignancy
Solid tumor
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