ATM Inhibitors in Cancer Radiotherapy: Mechanisms, Clinical Development, and Future Directions

ATM Inhibitors in Cancer Radiotherapy: Mechanisms, Clinical Development, and Future Directions

<p>Ataxia-telangiectasia mutated (ATM) kinase plays a pivotal role in the cellular response to DNA damage. Under normal conditions, ATM acts as a tumor suppressor by regulating pathways that lead to apoptosis and cell cycle arrest via effectors like p53, p21, CHK1, and CHK2. Paradoxically, in...

Full description

Saved in:
Bibliographic Details
Main Author: Raed.M. Al-Zoubi (22254577) (author)
Other Authors: Khalil Garada (22254580) (author), Reem Al Huneidi (22254583) (author), Zaid M.H. Baddar (22254586) (author), Ayman A. Zarour (17917709) (author), Mai Elaarag (17807390) (author), Sally R. Al-Zoubi (22254589) (author), Ahmad R. Al-Qudimat (17337808) (author), Mazhar Salim Al Zoubi (18024364) (author), Abdelali Agouni (181926) (author), Khalid Alrumaihi (14779210) (author)
Published: 2025
Subjects:
Biomedical and clinical sciences
Oncology and carcinogenesis
Pharmacology and pharmaceutical sciences
ATM inhibitors
Radiotherapy
Cancer therapy
DNA damage response
Clinical trials
Translational
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items