Corneal Confocal Microscopy Identifies Neurodegeneration in Relation to Disease Severity and Neuropathic Symptoms in Rosacea
<p><br></p><p dir="ltr">Rosacea affects at least 20 million people worldwide and is characterized by erythema, papules, pustules, telangiectasia, fibrosis, and burning sensation of the facial skin (<a href="" target="_blank">Steinhoff and B...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , , , , , , , , , , , |
| Published: |
2025
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | <p><br></p><p dir="ltr">Rosacea affects at least 20 million people worldwide and is characterized by erythema, papules, pustules, telangiectasia, fibrosis, and burning sensation of the facial skin (<a href="" target="_blank">Steinhoff and Bergstresser, 2011</a>). The underlying pathophysiology of rosacea is complex, although neurogenic inflammation is thought to play an important role, and altered cutaneous sensitivity is a hallmark of rosacea (<a href="" target="_blank">Sulk et al, 2012</a>). Ocular rosacea may affect >50% of patients with rosacea and is characterized by dryness and foreign body sensation (<a href="" target="_blank">Sinikumpu et al, 2022</a>).</p><p dir="ltr">Corneal confocal microscopy (CCM) is a noninvasive ophthalmic imaging technique that has been used to identify neurodegeneration in diabetic and other peripheral and central neurodegenerative diseases (<a href="" target="_blank">Petropoulos et al, 2020</a>) and to identify corneal conjuctivalization (<a href="" target="_blank">De Nicola et al, 2005</a>) and meibomian and skin gland alterations (<a href="" target="_blank">Liang et al, 2017</a>) in patients with rosacea. We now seek to demonstrate the utility of CCM to assess neurodegeneration in relation to disease onset and progression, subtypes, and treatment efficacy in patients with rosacea.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Investigative Dermatology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jid.2025.03.047" target="_blank">https://dx.doi.org/10.1016/j.jid.2025.03.047</a></p> |
|---|