Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12

Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12

<div><p>The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein levels are commonly downregulated in cancer. Here, using an shRNA li...

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Bibliographic Details
Main Author: Omar M. Khan (17807774) (author)
Other Authors: Jorge Almagro (8692275) (author), Jessica K. Nelson (3775789) (author), Stuart Horswell (594411) (author), Vesela Encheva (4917094) (author), Kripa S. Keyan (17807771) (author), Bruce E. Clurman (18595726) (author), Ambrosius P. Snijders (3192861) (author), Axel Behrens (47682) (author)
Published: 2021
Subjects:
Biomedical and clinical sciences
Oncology and carcinogenesis
Tumour suppressor
FBW7
E3 ubiquitin ligase
SKP1-CUL1-F-box (SCF) complex
Oncoproteins
Proteasomal degradation
Cancer
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