Flavin Adenine Dinucleotide (FAD) and Pyridoxal 5′-Phosphate (PLP) Bind to Sox9 and Alter the Expression of Key Pancreatic Progenitor Transcription Factors
<div><p>Cofactor flavin adenine dinucleotide (FAD), a compound with flavin moiety and a derivative of riboflavin (vitamin B2), is shown to bind to Sox9 (a key transcription factor in early pancreatic development) and, subsequently, induce a large increase in markers of pancreatic develop...
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2022
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| _version_ | 1864513519707226112 |
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| author | Zeyaul Islam (5867387) |
| author2 | Noura Aldous (15429873) Sunkyu Choi (2141545) Frank Schmidt (207186) Borbala Mifsud (3907267) Essam M. Abdelalim (5768072) Prasanna R. Kolatkar (124118) |
| author2_role | author author author author author author |
| author_facet | Zeyaul Islam (5867387) Noura Aldous (15429873) Sunkyu Choi (2141545) Frank Schmidt (207186) Borbala Mifsud (3907267) Essam M. Abdelalim (5768072) Prasanna R. Kolatkar (124118) |
| author_role | author |
| dc.creator.none.fl_str_mv | Zeyaul Islam (5867387) Noura Aldous (15429873) Sunkyu Choi (2141545) Frank Schmidt (207186) Borbala Mifsud (3907267) Essam M. Abdelalim (5768072) Prasanna R. Kolatkar (124118) |
| dc.date.none.fl_str_mv | 2022-11-14T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/ijms232214051 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Flavin_Adenine_Dinucleotide_FAD_and_Pyridoxal_5_-Phosphate_PLP_Bind_to_Sox9_and_Alter_the_Expression_of_Key_Pancreatic_Progenitor_Transcription_Factors/25514044 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Chemical sciences Inorganic chemistry Organic chemistry Theoretical and computational chemistry pancreatic progenitors Sox9 FAD PLP transcription factor Sox family |
| dc.title.none.fl_str_mv | Flavin Adenine Dinucleotide (FAD) and Pyridoxal 5′-Phosphate (PLP) Bind to Sox9 and Alter the Expression of Key Pancreatic Progenitor Transcription Factors |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Cofactor flavin adenine dinucleotide (FAD), a compound with flavin moiety and a derivative of riboflavin (vitamin B2), is shown to bind to Sox9 (a key transcription factor in early pancreatic development) and, subsequently, induce a large increase in markers of pancreatic development, including Ngn3 and PTF1a. Pyridoxal 5′-phosphate (PLP), the active form of vitamin B6, also binds to Sox9 and results in a similar increase in pancreatic development markers. Sox9 is known to be specifically important for pancreatic progenitors. Previously, there was no known link between FAD, PLP, or other co-factors and Sox9 for function. Thus, our findings show the mechanism by which FAD and PLP interact with Sox9 and result in the altered expression of pancreatic progenitor transcription factors involved in the pancreas development.</p><p> </p></div><h2>Other Information</h2> <p> Published in: International Journal of Molecular Sciences<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms232214051" target="_blank">https://dx.doi.org/10.3390/ijms232214051</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_96a495a977c1caf307d92b0384f48113 |
| identifier_str_mv | 10.3390/ijms232214051 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25514044 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Flavin Adenine Dinucleotide (FAD) and Pyridoxal 5′-Phosphate (PLP) Bind to Sox9 and Alter the Expression of Key Pancreatic Progenitor Transcription FactorsZeyaul Islam (5867387)Noura Aldous (15429873)Sunkyu Choi (2141545)Frank Schmidt (207186)Borbala Mifsud (3907267)Essam M. Abdelalim (5768072)Prasanna R. Kolatkar (124118)Chemical sciencesInorganic chemistryOrganic chemistryTheoretical and computational chemistrypancreatic progenitorsSox9FADPLPtranscription factorSox family<div><p>Cofactor flavin adenine dinucleotide (FAD), a compound with flavin moiety and a derivative of riboflavin (vitamin B2), is shown to bind to Sox9 (a key transcription factor in early pancreatic development) and, subsequently, induce a large increase in markers of pancreatic development, including Ngn3 and PTF1a. Pyridoxal 5′-phosphate (PLP), the active form of vitamin B6, also binds to Sox9 and results in a similar increase in pancreatic development markers. Sox9 is known to be specifically important for pancreatic progenitors. Previously, there was no known link between FAD, PLP, or other co-factors and Sox9 for function. Thus, our findings show the mechanism by which FAD and PLP interact with Sox9 and result in the altered expression of pancreatic progenitor transcription factors involved in the pancreas development.</p><p> </p></div><h2>Other Information</h2> <p> Published in: International Journal of Molecular Sciences<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms232214051" target="_blank">https://dx.doi.org/10.3390/ijms232214051</a></p>2022-11-14T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/ijms232214051https://figshare.com/articles/journal_contribution/Flavin_Adenine_Dinucleotide_FAD_and_Pyridoxal_5_-Phosphate_PLP_Bind_to_Sox9_and_Alter_the_Expression_of_Key_Pancreatic_Progenitor_Transcription_Factors/25514044CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/255140442022-11-14T03:00:00Z |
| spellingShingle | Flavin Adenine Dinucleotide (FAD) and Pyridoxal 5′-Phosphate (PLP) Bind to Sox9 and Alter the Expression of Key Pancreatic Progenitor Transcription Factors Zeyaul Islam (5867387) Chemical sciences Inorganic chemistry Organic chemistry Theoretical and computational chemistry pancreatic progenitors Sox9 FAD PLP transcription factor Sox family |
| status_str | publishedVersion |
| title | Flavin Adenine Dinucleotide (FAD) and Pyridoxal 5′-Phosphate (PLP) Bind to Sox9 and Alter the Expression of Key Pancreatic Progenitor Transcription Factors |
| title_full | Flavin Adenine Dinucleotide (FAD) and Pyridoxal 5′-Phosphate (PLP) Bind to Sox9 and Alter the Expression of Key Pancreatic Progenitor Transcription Factors |
| title_fullStr | Flavin Adenine Dinucleotide (FAD) and Pyridoxal 5′-Phosphate (PLP) Bind to Sox9 and Alter the Expression of Key Pancreatic Progenitor Transcription Factors |
| title_full_unstemmed | Flavin Adenine Dinucleotide (FAD) and Pyridoxal 5′-Phosphate (PLP) Bind to Sox9 and Alter the Expression of Key Pancreatic Progenitor Transcription Factors |
| title_short | Flavin Adenine Dinucleotide (FAD) and Pyridoxal 5′-Phosphate (PLP) Bind to Sox9 and Alter the Expression of Key Pancreatic Progenitor Transcription Factors |
| title_sort | Flavin Adenine Dinucleotide (FAD) and Pyridoxal 5′-Phosphate (PLP) Bind to Sox9 and Alter the Expression of Key Pancreatic Progenitor Transcription Factors |
| topic | Chemical sciences Inorganic chemistry Organic chemistry Theoretical and computational chemistry pancreatic progenitors Sox9 FAD PLP transcription factor Sox family |