Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline

Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline

<p dir="ltr">In somatic cells/tissues, methylation of ribosomal DNA (rDNA) increases with age and age‐related pathologies, which has a direct impact on the regulation of nucleolar activity and cellular metabolism. Here, we used bisulfite pyrosequencing and show that methylation of th...

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Bibliographic Details
Main Author: Ramya Potabattula (4401160) (author)
Other Authors: Federica Zacchini (289957) (author), Grazyna Ewa Ptak (18877204) (author), Marcus Dittrich (167737) (author), Tobias Müller (163591) (author), Nady El Hajj (686554) (author), Thomas Hahn (146530) (author), Charis Drummer (18710925) (author), Rüdiger Behr (705041) (author), Andrea Lucas‐Hahn (18877207) (author), Heiner Niemann (196135) (author), Martin Schorsch (686559) (author), Thomas Haaf (342924) (author)
Published: 2020
Subjects:
Biological sciences
Genetics
Biomedical and clinical sciences
Reproductive medicine
embryo developmental potential
epigenetic clock
germline aging
repetitive DNA elements
ribosomal DNA
sperm DNA methylation
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