Arrhythmia-Associated Calmodulin E105A Mutation Alters the Binding Affinity of CaM to a Ryanodine Receptor 2 CaM-Binding Pocket

Arrhythmia-Associated Calmodulin E105A Mutation Alters the Binding Affinity of CaM to a Ryanodine Receptor 2 CaM-Binding Pocket

<p dir="ltr">Calmodulin (CaM) is a small, multifunctional calcium (Ca<sup>2+</sup>)-binding sensor that binds and regulates the open probability of cardiac ryanodine receptor 2 (RyR2) at both low and high cytosolic Ca<sup>2+</sup> concentrations. Recent isothe...

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Bibliographic Details
Main Author: Angelos Thanassoulas (2822861) (author)
Other Authors: Maria Theodoridou (33087) (author), Laila Barrak (17714490) (author), Emna Riguene (17714493) (author), Tamader Alyaarabi (17714496) (author), Mohamed A. Elrayess (7956179) (author), F. Anthony Lai (17714499) (author), Michail Nomikos (17563188) (author)
Published: 2023
Subjects:
Biomedical and clinical sciences
Cardiovascular medicine and haematology
Medical physiology
Chemical sciences
Medicinal and biomolecular chemistry
calmodulin
ryanodine receptor
RyR2
arrhythmias
cardiac disease
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