Downregulation of <i>CYP17A1</i> by 20-hydroxyecdysone: plasma progesterone and its vasodilatory properties

Downregulation of <i>CYP17A1</i> by 20-hydroxyecdysone: plasma progesterone and its vasodilatory properties

<p dir="ltr">Aim: To investigate the effect of 20-hydroxyecdysone on steroidogenic pathway genes and plasma progesterone, and its potential impact on vascular functions. Methods: Chimeric mice with humanized liver were treated with 20-hydroxyecdysone for 3 days, and hepatic steroidog...

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Bibliographic Details
Main Author: Maneera Y Aljaber (18278971) (author)
Other Authors: Nelson N Orie (18278974) (author), Asmaa Raees (18278977) (author), Suhail Kraiem (18278980) (author), Mashael Al-Jaber (18278983) (author), Waseem Samsam (12204880) (author), Mostafa M Hamza (18278986) (author), David Abraham (36404) (author), Norman M Kneteman (18278989) (author), Alka Beotra (14780368) (author), Vidya Mohamed-Ali (12204895) (author), Mohammed Almaadheed (18278992) (author)
Published: 2022
Subjects:
Biomedical and clinical sciences
Clinical sciences
Medical biotechnology
Pharmacology and pharmaceutical sciences
20-hydroxyecdysone
CYP17A1
ecdysteroid
hepatic transcriptome
humanized liver
mesenteric arteriole
muscle arteriole
progesterone
vasodilation
voltage-dependent calcium entry
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