Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells

Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells

<div><p>S-phase kinase-associated protein2 (Skp2), a proto-oncoprotein, plays an important role in development and progression of human malignancies. Skp2 is frequently overexpressed in many human malignancies. It targets cell cycle progression through ubiquitin mediated degradation of G...

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Bibliographic Details
Main Author: Abdul Q. Khan (14153247) (author)
Other Authors: Kodappully S. Siveen (4246150) (author), Kirti S. Prabhu (4246144) (author), Shilpa Kuttikrishnan (3520079) (author), Sabah Akhtar (5809925) (author), Abdullah Shaar (5809928) (author), Afsheen Raza (492657) (author), Fatima Mraiche (715733) (author), Said Dermime (79420) (author), Shahab Uddin (154400) (author)
Published: 2018
Subjects:
Biomedical and clinical sciences
Oncology and carcinogenesis
cancer
head and neck squamous cell carcinoma
HPV
Skp2
apoptosis
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