Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains

Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains

<h3>Background</h3><p dir="ltr">Alpha-synuclein (α-syn) aggregation into proteinaceous intraneuronal inclusions, called Lewy bodies (LBs), is the neuropathological hallmark of Parkinson’s disease (PD) and related synucleinopathies. However, the exact role of α-syn inclusi...

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Bibliographic Details
Main Author: Morgan Bérard (12219298) (author)
Other Authors: Laura Martínez-Drudis (17460758) (author), Razan Sheta (3825544) (author), Omar M. A. El-Agnaf (8809331) (author), Abid Oueslati (816135) (author)
Published: 2023
Subjects:
Biomedical and clinical sciences
Clinical sciences
Neurosciences
Alpha-synuclein
Adeno-associated virus
AAV-PHP.eB
Neurodegeneration Parkinson’s
Disease Animal model
Systemic delivery .
PD-like symptoms
Genetic model of PD
Protein aggregation
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