Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains

Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains

<h3>Background</h3><p dir="ltr">Alpha-synuclein (α-syn) aggregation into proteinaceous intraneuronal inclusions, called Lewy bodies (LBs), is the neuropathological hallmark of Parkinson’s disease (PD) and related synucleinopathies. However, the exact role of α-syn inclusi...

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Bibliographic Details
Main Author:	Morgan Bérard (12219298) (author)
Other Authors:	Laura Martínez-Drudis (17460758) (author), Razan Sheta (3825544) (author), Omar M. A. El-Agnaf (8809331) (author), Abid Oueslati (816135) (author)
Published:	2023
Subjects:	Biomedical and clinical sciences Clinical sciences Neurosciences Alpha-synuclein Adeno-associated virus AAV-PHP.eB Neurodegeneration Parkinson’s Disease Animal model Systemic delivery . PD-like symptoms Genetic model of PD Protein aggregation
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