Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes

Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes

<div><p>Obesity promotes premature aging and dysfunction of white adipose tissue (WAT) through the accumulation of cellular senescence. The senescent cells burden in WAT has been linked to inflammation, insulin-resistance (IR), and type 2 diabetes (T2D). There is limited knowledge about...

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Main Author: Aisha Y. Madani (14152911) (author)
Other Authors: Yasser Majeed (9417974) (author), Houari B. Abdesselem (14152827) (author), Maha V. Agha (7956170) (author), Muneera Vakayil (12037693) (author), Nour K. Al Sukhun (18527763) (author), Najeeb M. Halabi (1297779) (author), Pankaj Kumar (63234) (author), Shahina Hayat (8774135) (author), Mohamed A. Elrayess (7956179) (author), Arash Rafii (102768) (author), Karsten Suhre (67967) (author), Nayef A. Mazloum (7355087) (author)
Published: 2021
Subjects:
Biological sciences
Biochemistry and cell biology
cellular senescence
inflammation
ROS
preadipocytes
SASP
type 2 diabetes
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