MicroRNA-3148 acts as molecular switch promoting malignant transformation and adipocytic differentiation of immortalized human bone marrow stromal cells via direct targeting of the SMAD2/TGFβ pathway

MicroRNA-3148 acts as molecular switch promoting malignant transformation and adipocytic differentiation of immortalized human bone marrow stromal cells via direct targeting of the SMAD2/TGFβ pathway

<p dir="ltr">MicroRNAs (miRs/miRNAs) play a key role in posttranscriptional regulation of gene expression and are implicated in a number of physiological and pathological conditions, including cellular malignant transformation. In the current study, we investigated the role of miR-31...

Full description

Saved in:

Bibliographic Details
Main Author:	Radhakrishnan Vishnubalaji (3563306) (author)
Other Authors:	Ramesh Elango (7542068) (author), Muthurangan Manikandan (6002243) (author), Abdul-Aziz Siyal (18619237) (author), Dalia Ali (6002237) (author), Ammar Al-Rikabi (5213753) (author), Dana Hamam (3400181) (author), Rimi Hamam (3563312) (author), Hicham Benabdelkamel (2094556) (author), Afshan Masood (8279052) (author), Ibrahim O. Alanazi (3219180) (author), Assim A. Alfadda (9674998) (author), Musaad Alfayez (3571736) (author), Abdullah Aldahmash (3563300) (author), Moustapha Kassem (101848) (author), Nehad M. Alajez (7397276) (author)
Published:	2020
Subjects:	Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Medical biotechnology Oncology and carcinogenesis MicroRNAs Stem Cells miR-3148 Adipocytic Differentiation Carcinogenesis Sarcoma Proteomic Analysis
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via <i>LIN28B</i>
by: Radhakrishnan Vishnubalaji (3563306)
Published: (2019)

Real-world clinical outcomes with daily image-guided IMRT in extremity soft tissue sarcomas
by: Venkada Manickam Gurusamy (17346805)
Published: (2022)

Role of microRNA 690 in Mediating Angiotensin II Effects on Inflammation and Endoplasmic Reticulum Stress
by: Kalhara R. Menikdiwela (18566698)
Published: (2020)

Epigenetic regulation of triple negative breast cancer (TNBC) by TGF-β signaling
by: Radhakrishnan Vishnubalaji (3563306)
Published: (2021)

Primary Mediastinal Ewing sarcoma presenting as a massive lung lesion with a mediastinal shift
by: Fateen Ata (12217764)
Published: (2021)

Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation
by: Mona Elsafadi (18614905)
Published: (2019)

Isolated right oculomotor nerve palsy as the first presenting manifestation of metastatic renal Ewing’s sarcoma
by: Abdulrahman F. Al-Mashdali (17148316)
Published: (2022)

MicroRNA Expression Profiling on Paired Primary and Lymph Node Metastatic Breast Cancer Revealed Distinct microRNA Profile Associated With LNM
by: Ramesh Elango (7542068)
Published: (2020)

Whole genome mRNA expression profiling revealed multiple deregulated pathways in stromal vascular fraction from erectile dysfunction patients
by: Radhakrishnan Vishnubalaji (3563306)
Published: (2018)

Long non-coding RNA (lncRNA) transcriptional landscape in breast cancer identifies LINC01614 as non-favorable prognostic biomarker regulated by TGFβ and focal adhesion kinase (FAK) signaling
by: Radhakrishnan Vishnubalaji (3563306)
Published: (2019)

Author Correction: Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation
by: Mona Elsafadi (18614905)
Published: (2019)

Extra-skeletal Ewing's sarcoma, a rare condition of the submandibular salivary gland, a case report
by: Abdul-Aziz Alaqeeli (21323699)
Published: (2022)

The Role of AEBP1 in Sex-Specific Diet-Induced Obesity
by: Zhang, Lei
Published: (2005)

Reciprocal interplays between MicroRNAs and pluripotency transcription factors in dictating stemness features in human cancers
by: Radhakrishnan Vishnubalaji (3563306)
Published: (2022)

The trans-10, cis-12 isomer of conjugated linoleic acid decreases adiponectin assembly by PPARγ-dependent and PPARγ-independent mechanisms
by: Miller, Jessica R.
Published: (2008)

Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Proinflammatory Mediator) Overexpression Promotes and Ablation Attenuates Atherosclerosis in ApoE⁻′⁻ and LDLR⁻′⁻ Mice
by: Bogachev, Oleg
Published: (2011)

Breast cancer cells and bone marrow mesenchymal stromal cells
by: Faour, Wissam H.
Published: (2017)

Integrated Transcriptome and Pathway Analyses Revealed Multiple Activated Pathways in Breast Cancer
by: Radhakrishnan Vishnubalaji (3563306)
Published: (2019)

Congenital myofibroblastic fibrosarcoma of the temporal bone in a newborn Arabian foal
by: Jessica P. Johnson (17991478)
Published: (2025)

Long non-coding RNA AC099850.4 correlates with advanced disease state and predicts worse prognosis in triple-negative breast cancer
by: Radhakrishnan Vishnubalaji (3563306)
Published: (2023)

Single-Cell Transcriptome Analysis Revealed Heterogeneity and Identified Novel Therapeutic Targets for Breast Cancer Subtypes
by: Radhakrishnan Vishnubalaji (3563306)
Published: (2023)

Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome
by: Fayaz Ahmad Mir (11828354)
Published: (2022)

miRCOVID-19: Potential Targets of Human miRNAs in SARS-CoV-2 for RNA-Based Drug Discovery
by: Tanvir Alam (638619)
Published: (2021)

Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
by: Shaza B. Zaghlool (10836602)
Published: (2020)

Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory Response
by: Radhakrishnan Vishnubalaji (3563306)
Published: (2020)

Caloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice
by: Charlotte Rinne (18766966)
Published: (2024)

Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment
by: Seán Fitzgerald (721911)
Published: (2018)

CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors
by: Mashael Al-toub (3563303)
Published: (2022)

The link between glycemic control measures and eye microvascular complications in a clinical cohort of type 2 diabetes with microRNA-223-3p signature
by: Sahar I. Da’as (9631717)
Published: (2023)

Stromal Adipocyte Enhancer-binding Protein (AEBP1) Promotes Mammary Epithelial Cell Hyperplasia via Proinflammatory and Hedgehog Signaling
by: Holloway, Ryan W.
Published: (2012)

MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles
by: Micol Marchetti (18623410)
Published: (2020)

Control of TGFβ signalling by ubiquitination independent function of E3 ubiquitin ligase TRIP12
by: Kripa S Keyan (10644815)
Published: (2023)

Comparative effectiveness and safety of direct-acting oral anticoagulants (DOACS) for the reduction of recurrent venous thromboembolism in cancer patients
by: Mohammed ibn-Mas’ud Danjuma (20278119)
Published: (2020)

Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis
by: Sophie Hawkins (18421377)
Published: (2022)

The role of microRNAs in skin cancers
by: Nature Research (16552612)
Published: (2015)

Transgelin is a poor prognostic factor associated with advanced colorectal cancer (CRC) stage promoting tumor growth and migration in a TGFβ-dependent manner
by: Mona Elsafadi (18614905)
Published: (2020)

The Role of Apolipoproteins in the Commonest Cancers: A Review
by: Nour M. Darwish (18192730)
Published: (2023)

Predictive value of tyrosine phosphatase receptor gamma for the response to treatment tyrosine kinase inhibitors in chronic myeloid leukemia patients
by: Mohamed A. Ismail (418629)
Published: (2022)

Acting in the public interest
by: Benton, David C.
Published: (2019)

LncRNA-Based Classification of Triple Negative Breast Cancer Revealed Inherent Tumor Heterogeneity and Vulnerabilities
by: Radhakrishnan Vishnubalaji (3563306)
Published: (2022)