Ratios of Acetaminophen Metabolites Identify New Loci of Pharmacogenetic Relevance in a Genome-Wide Association Study

Ratios of Acetaminophen Metabolites Identify New Loci of Pharmacogenetic Relevance in a Genome-Wide Association Study

<div><p>Genome-wide association studies (GWAS) with non-targeted metabolomics have identified many genetic loci of biomedical interest. However, metabolites with a high degree of missingness, such as drug metabolites and xenobiotics, are often excluded from such studies due to a lack of...

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Bibliographic Details
Main Author: Gaurav Thareja (459188) (author)
Other Authors: Anne M. Evans (127464) (author), Spencer D. Wood (18418539) (author), Nisha Stephan (17445912) (author), Shaza Zaghlool (3466298) (author), Anna Halama (545988) (author), Gabi Kastenmüller (127487) (author), Aziz Belkadi (779313) (author), Omar M. E. Albagha (11704871) (author), Karsten Suhre (67967) (author), The Qatar Genome Program Research Consortium (14778616) (author)
Published: 2022
Subjects:
Biological sciences
Biochemistry and cell biology
Biomedical and clinical sciences
Clinical sciences
medication
drug metabolites
population studies
non-targeted metabolomics
genome-wide association studies
acetaminophen metabolism
pharmacogenomics
3-methoxyacetaminophen
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