Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome

Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome

<h3>Background</h3><p dir="ltr">Inborn errors of immunity (IEI) and autoantibodies to type I interferons (IFNs) underlie critical COVID-19 pneumonia in at least 15% of the patients, while the causes of multisystem inflammatory syndrome in children (MIS-C) remain elusive.&...

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Main Author: Hassan Abolhassani (2287858) (author)
Other Authors: Nils Landegren (621152) (author), Paul Bastard (12967485) (author), Marie Materna (18387156) (author), Mohammadreza Modaresi (18387159) (author), Likun Du (92985) (author), Maribel Aranda-Guillén (18173923) (author), Fabian Sardh (18387162) (author), Fanglei Zuo (3232698) (author), Peng Zhang (2071) (author), Harold Marcotte (35624) (author), Nico Marr (349853) (author), Taushif Khan (691254) (author), Manar Ata (9046473) (author), Fatima Al-Ali (14151237) (author), Remi Pescarmona (18387165) (author), Alexandre Belot (282871) (author), Vivien Béziat (204259) (author), Qian Zhang (49333) (author), Jean-Laurent Casanova (64712) (author), Olle Kämpe (138981) (author), Shen-Ying Zhang (140174) (author), Lennart Hammarström (35623) (author), Qiang Pan-Hammarström (92996) (author)
Published: 2022
Subjects:
Biomedical and clinical sciences
Immunology
COVID-19
critical pneumonia
multisystem inflammatory syndrome in children (MIS-C)
inborn errors of immunity (IEI)
primary immunodeficiency (PID)
IFNAR1
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