Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity

Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity

<p>Synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are characterized by pathological accumulation of α-synuclein (α-syn). Amongst the various approaches attempting to tackle the pathological features of synucleinopathies,...

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Main Author: Vijay Gupta (209146) (author)
Other Authors: Safa Salim (9186786) (author), Issam Hmila (9239059) (author), Nishant N. Vaikath (2901785) (author), Indulekha P. Sudhakaran (9611154) (author), Simona S. Ghanem (12267227) (author), Nour K. Majbour (8809316) (author), Sara A. Abdulla (13902015) (author), Mohamed M. Emara (9913215) (author), Houari B. Abdesselem (14152827) (author), Tamas Lukacsovich (23182) (author), Daniel Erskine (3471959) (author), Omar M. A. El-Agnaf (8809331) (author)
Published: 2020
Subjects:
Biological sciences
Biochemistry and cell biology
Biomedical and clinical sciences
Neurosciences
Parkinson's disease
Dementia with Lewy bodies
Multiple system atrophy
Neurodegeneration
Immunotherapy
Antibody engineering
Protein purification
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