Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1α Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study

Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1α Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study

<h3>Background</h3><p dir="ltr">Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1). For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional coactivator p300, a critic...

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Bibliographic Details
Main Author: Muhammad Suleman (3829027) (author)
Other Authors: Abrar Mohammad Sayaf (11644294) (author), Sohail Aftab (22443284) (author), Mohammed Alissa (18607830) (author), Abdullah Alghamdi (14375904) (author), Suad A. Alghamdi (21998691) (author), Mohammed A. Alshehri (18696547) (author), Kar Kheng Yeoh (1933633) (author), Sergio Crovella (20921252) (author), Abdullah Shaito (20545181) (author)
Published: 2025
Subjects:
Biological sciences
Biochemistry and cell biology
Bioinformatics and computational biology
Biomedical and clinical sciences
Oncology and carcinogenesis
Pharmacology and pharmaceutical sciences
Chemical sciences
Medicinal and biomolecular chemistry
Health sciences
Traditional, complementary and integrative medicine
p300
HIF-1
hypoxia
phytocompounds
drug screening
MD simulation
binding free energy
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