Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways

Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways

<p>HER2-positive breast cancer is one of its most challenging subtypes, forming around 15–25% of the total cases. It is characterized by aggressive behavior and treatment resistance. On the other hand, poly (amidoamine) (PAMAM) dendrimers are widely used in drug delivery systems and gene trans...

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Bibliographic Details
Main Author: Hadeel Kheraldine (14231609) (author)
Other Authors: Ishita Gupta (9203073) (author), Hashim Alhussain (9167136) (author), Aayesha Jabeen (20414090) (author), Farhan S. Cyprian (11924492) (author), Saghir Akhtar (319652) (author), Ala-Eddin Al Moustafa (14153205) (author), Ousama Rachid (14158917) (author)
Published: 2021
Subjects:
Biomedical and clinical sciences
Medical biotechnology
Oncology and carcinogenesis
Pharmacology and pharmaceutical sciences
PAMAMs
HER2-positive
Breast cancer
Chemoprevention
Apoptosis
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