Pharmacophore-based virtual screening approaches to identify novel molecular candidates against EGFR through comprehensive computational approaches and in-vitro studies

Pharmacophore-based virtual screening approaches to identify novel molecular candidates against EGFR through comprehensive computational approaches and in-vitro studies

<div><p>Alterations to the EGFR (epidermal growth factor receptor) gene, which primarily occur in the axon 18–21 position, have been linked to a variety of cancers, including ovarian, breast, colon, and lung cancer. The use of TK inhibitors (gefitinib, erlotinib, lapatinib, and afatinib)...

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Main Author: F A Dain Md Opo (14123109) (author)
Other Authors: Mohammed Moulay (575948) (author), Ali Zari (12083666) (author), Afnan Alqaderi (14123112) (author), Saleh Alkarim (5914538) (author), Talal Zari (14123115) (author), Mohiuddin Ahmed Bhuiyan (9670038) (author), Maged Mostafa Mahmoud (14123118) (author), Fadwa Aljoud (14123121) (author), Mohd Suhail (528221) (author), Sherif Edris (521439) (author), Wafaa S. Ramadan (10538127) (author), Mohammad Amjad Kamal (9604771) (author), Saïd Nemmiche (14123124) (author), Foysal Ahammad (9286524) (author)
Published: 2022
Subjects:
Biomedical and clinical sciences
Pharmacology and pharmaceutical sciences
EGFR
side effects
cell toxicity
in-vitro
inhibitors
gefitinib
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