Transcriptomic Profiling of Tumor-Infiltrating CD4<sup>+</sup>TIM-3<sup>+</sup> T Cells Reveals Their Suppressive, Exhausted, and Metastatic Characteristics in Colorectal Cancer Patients

Transcriptomic Profiling of Tumor-Infiltrating CD4<sup>+</sup>TIM-3<sup>+</sup> T Cells Reveals Their Suppressive, Exhausted, and Metastatic Characteristics in Colorectal Cancer Patients

<p dir="ltr">T cell immunoglobulin mucin-3 (TIM-3) is an immune checkpoint identified as one of the key players in regulating T-cell responses. Studies have shown that TIM-3 is upregulated in the tumor microenvironment (TME). However, the precise role of TIM-3 in colorectal cancer (C...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Varun Sasidharan Nair (5396393) (author)
مؤلفون آخرون: Salman M Toor (18623267) (author), Rowaida Z Taha (18719002) (author), Ayman A Ahmed (18719005) (author), Mohamed A Kurer (18719008) (author), Khaled Murshed (8309781) (author), Madiha E Soofi (18719011) (author), Khalid Ouararhni (3145734) (author), Nehad M. Alajez (18197) (author), Mohamed Abu Nada (8309784) (author), Eyad Elkord (5396390) (author)
منشور في: 2020
الموضوعات:
Biomedical and clinical sciences
Immunology
Medical biochemistry and metabolomics
Oncology and carcinogenesis
colorectal cancer
tumor microenvironment
T cell immunoglobulin mucin-3
exhausted T cells
metastasis
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