B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention
<p dir="ltr">B7-H3 (B7 homology 3 protein) is an important transmembrane immunoregulatory protein expressed in immune cells, antigen-presenting cells, and tumor cells. Studies reveal a multifaceted role of B7-H3 in tumor progression by modulating various cancer hallmarks involving an...
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2023
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| _version_ | 1864513521135386624 |
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| author | Elizabeth Varghese (11008845) |
| author2 | Samson Mathews Samuel (11008848) Aranka Brockmueller (11064675) Mehdi Shakibaei (325455) Peter Kubatka (11008854) Dietrich Büsselberg (11008857) |
| author2_role | author author author author author |
| author_facet | Elizabeth Varghese (11008845) Samson Mathews Samuel (11008848) Aranka Brockmueller (11064675) Mehdi Shakibaei (325455) Peter Kubatka (11008854) Dietrich Büsselberg (11008857) |
| author_role | author |
| dc.creator.none.fl_str_mv | Elizabeth Varghese (11008845) Samson Mathews Samuel (11008848) Aranka Brockmueller (11064675) Mehdi Shakibaei (325455) Peter Kubatka (11008854) Dietrich Büsselberg (11008857) |
| dc.date.none.fl_str_mv | 2023-09-28T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s10555-023-10137-8 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/B7-H3_at_the_crossroads_between_tumor_plasticity_and_colorectal_cancer_progression_a_potential_target_for_therapeutic_intervention/24981189 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Immunology Oncology and carcinogenesis Colorectal cancer B7-H3 Immunomodulation Tumor plasticity, immune checkpoint Drug resistance |
| dc.title.none.fl_str_mv | B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">B7-H3 (B7 homology 3 protein) is an important transmembrane immunoregulatory protein expressed in immune cells, antigen-presenting cells, and tumor cells. Studies reveal a multifaceted role of B7-H3 in tumor progression by modulating various cancer hallmarks involving angiogenesis, immune evasion, and tumor microenvironment, and it is also a promising candidate for cancer immunotherapy. In colorectal cancer (CRC), B7-H3 has been associated with various aspects of disease progression, such as evasion of tumor immune surveillance, tumor-node metastasis, and poor prognosis. Strategies to block or interfere with B7-H3 in its immunological and non-immunological functions are under investigation. In this study, we explore the role of B7-H3 in tumor plasticity, emphasizing tumor glucose metabolism, angiogenesis, epithelial-mesenchymal transition, cancer stem cells, apoptosis, and changing immune signatures in the tumor immune landscape. We discuss how B7-H3-induced tumor plasticity contributes to immune evasion, metastasis, and therapy resistance. Furthermore, we delve into the most recent advancements in targeting B7-H3-based tumor immunotherapy as a potential approach to CRC treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancer and Metastasis Reviews<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s10555-023-10137-8" target="_blank">https://dx.doi.org/10.1007/s10555-023-10137-8</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e875e6ba368f6c38503a31aefaee7788 |
| identifier_str_mv | 10.1007/s10555-023-10137-8 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24981189 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic interventionElizabeth Varghese (11008845)Samson Mathews Samuel (11008848)Aranka Brockmueller (11064675)Mehdi Shakibaei (325455)Peter Kubatka (11008854)Dietrich Büsselberg (11008857)Biological sciencesGeneticsBiomedical and clinical sciencesImmunologyOncology and carcinogenesisColorectal cancerB7-H3ImmunomodulationTumor plasticity, immune checkpointDrug resistance<p dir="ltr">B7-H3 (B7 homology 3 protein) is an important transmembrane immunoregulatory protein expressed in immune cells, antigen-presenting cells, and tumor cells. Studies reveal a multifaceted role of B7-H3 in tumor progression by modulating various cancer hallmarks involving angiogenesis, immune evasion, and tumor microenvironment, and it is also a promising candidate for cancer immunotherapy. In colorectal cancer (CRC), B7-H3 has been associated with various aspects of disease progression, such as evasion of tumor immune surveillance, tumor-node metastasis, and poor prognosis. Strategies to block or interfere with B7-H3 in its immunological and non-immunological functions are under investigation. In this study, we explore the role of B7-H3 in tumor plasticity, emphasizing tumor glucose metabolism, angiogenesis, epithelial-mesenchymal transition, cancer stem cells, apoptosis, and changing immune signatures in the tumor immune landscape. We discuss how B7-H3-induced tumor plasticity contributes to immune evasion, metastasis, and therapy resistance. Furthermore, we delve into the most recent advancements in targeting B7-H3-based tumor immunotherapy as a potential approach to CRC treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancer and Metastasis Reviews<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s10555-023-10137-8" target="_blank">https://dx.doi.org/10.1007/s10555-023-10137-8</a></p>2023-09-28T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s10555-023-10137-8https://figshare.com/articles/journal_contribution/B7-H3_at_the_crossroads_between_tumor_plasticity_and_colorectal_cancer_progression_a_potential_target_for_therapeutic_intervention/24981189CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/249811892023-09-28T03:00:00Z |
| spellingShingle | B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention Elizabeth Varghese (11008845) Biological sciences Genetics Biomedical and clinical sciences Immunology Oncology and carcinogenesis Colorectal cancer B7-H3 Immunomodulation Tumor plasticity, immune checkpoint Drug resistance |
| status_str | publishedVersion |
| title | B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention |
| title_full | B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention |
| title_fullStr | B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention |
| title_full_unstemmed | B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention |
| title_short | B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention |
| title_sort | B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention |
| topic | Biological sciences Genetics Biomedical and clinical sciences Immunology Oncology and carcinogenesis Colorectal cancer B7-H3 Immunomodulation Tumor plasticity, immune checkpoint Drug resistance |