B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention

B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention

<p dir="ltr">B7-H3 (B7 homology 3 protein) is an important transmembrane immunoregulatory protein expressed in immune cells, antigen-presenting cells, and tumor cells. Studies reveal a multifaceted role of B7-H3 in tumor progression by modulating various cancer hallmarks involving an...

Full description

Saved in:

Bibliographic Details
Main Author:	Elizabeth Varghese (11008845) (author)
Other Authors:	Samson Mathews Samuel (11008848) (author), Aranka Brockmueller (11064675) (author), Mehdi Shakibaei (325455) (author), Peter Kubatka (11008854) (author), Dietrich Büsselberg (11008857) (author)
Published:	2023
Subjects:	Biological sciences Genetics Biomedical and clinical sciences Immunology Oncology and carcinogenesis Colorectal cancer B7-H3 Immunomodulation Tumor plasticity, immune checkpoint Drug resistance
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients
by: Salman M. Toor (8854751)
Published: (2019)

The complex network of transcription factors, immune checkpoint inhibitors and stemness features in colorectal cancer: A recent update
by: Maysaloun Merhi (4246147)
Published: (2023)

Expression of immune checkpoints and T cell exhaustion markers in early and advanced stages of colorectal cancer
by: Reem Saleh (3513056)
Published: (2020)

Tumor-Infiltrating Lymphoid Cells in Colorectal Cancer Patients with Varying Disease Stages and Microsatellite Instability-High/Stable Tumors
by: Salman M. Toor (8854751)
Published: (2021)

Intratumoral FoxP3<sup>+</sup>Helios<sup>+</sup> Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer
by: Azharuddin Sajid Syed Khaja (19720114)
Published: (2017)

DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer
by: Varun Sasidharan Nair (5396393)
Published: (2018)

Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications
by: Jessica Roelands (7516439)
Published: (2017)

Automatic Plastic Bottle Classification System for Recycling
by: Tachwali, Yahia
Published: (2005)

Sesamum indicum (sesame) enhances NK anti-cancer activity, modulates Th1/Th2 balance, and suppresses macrophage inflammatory response
by: Majdalawieh, Amin
Published: (2020)

Therapeutic targeting of the TPX2/TTK network in colorectal cancer
by: Hibah Shaath (5599658)
Published: (2023)

Anti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression
by: Elizabeth Varghese (11008845)
Published: (2020)

Vitamin D Signaling in Inflammation and Cancer: Molecular Mechanisms and Therapeutic Implications
by: Ahmed El-Sharkawy (20318388)
Published: (2020)

AEO‑7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos
by: Al‑Asmakh, Maha
Published: (2020)

Delineating and preventing plastic waste leakage in the marine and terrestrial environment
by: John N. Hahladakis (14151018)
Published: (2022)

Delineating the global plastic marine litter challenge: clarifying the misconceptions
by: John N. Hahladakis (14151018)
Published: (2020)

Photocatalytic UV degradation of 2,3,7,8-tetrachlorodibenzofuran in the presence of silver zeolite
by: Samara, Fatin
Published: (2017)

Environmental impacts of using recycled plastics in concrete
by: Furqan Tahir (14429547)
Published: (2022)

Novel Synonymous Variant in<i> IL7R</i> Causes Preferential Expression of the Soluble Isoform
by: Rafah Mackeh (14151225)
Published: (2024)

The molecular mechanisms of plasticity in crystal forms of theophylline
by: Liu, Hongji
Published: (2023)

The supramolecular host-guest complexation of Vemurafenib with β-cyclodextrin and cucurbit[7]uril as drug photoprotecting systems: A DFT/TD-DFT study
by: Abdulilah Dawoud, Bani-Yaseen
Published: (2020)

The effect of novel nitrogen-based chalcone analogs on colorectal cancer cells: Insight into the molecular pathways
by: Arij Fouzat, Hassan
Published: (2024)

Plastic waste impact and biotechnology: Exploring polymer degradation, microbial role, and sustainable development implications
by: Isra E. Gilani (17019066)
Published: (2023)

Role of circular RNAs in colorectal tumor microenvironment
by: Jasni Viralippurath Ashraf (16931820)
Published: (2021)

The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms
by: Farah Karam (22330564)
Published: (2025)

Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19
by: Majdalawieh, Amin
Published: (2021)

Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients
by: Salman M. Toor (8854751)
Published: (2016)

Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment
by: Seán Fitzgerald (721911)
Published: (2018)

Loss of the Fbw7 tumor suppressor rewires cholesterol metabolism in cancer cells leading to activation of the PI3K-AKT signalling axis
by: Maria T. Bengoechea-Alonso (13355331)
Published: (2022)

A Robotic System for Automatic Identification and Collection of Recyclable Plastic Bottles
by: Din, Uzma Ahmed
Published: (2020)

Transcriptome of Tumor-Infiltrating T Cells in Colorectal Cancer Patients Uncovered a Unique Gene Signature in CD4+ T Cells Associated with Poor Disease-Specific Survival
by: Salman M. Toor (8854751)
Published: (2021)

A scoping review on the European Union agricultural plastic waste management strategies: focusing on liquefaction
by: Chrysanthos, Maraveas
Published: (2025)

The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases?
by: Amira Kohil (15257285)
Published: (2023)

The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer
by: Kodappully S. Siveen (4246150)
Published: (2019)

Adoption and implementation of robotic colorectal surgery using structured training approach: an experience from tertiary referral center
by: Mahmood Al Dhaheri (21406826)
Published: (2025)

Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief Review
by: Queenie Fernandes (14557388)
Published: (2020)

Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer
by: Afsheen Raza (492657)
Published: (2022)

Comparison between the American code ASCE7-16 and the Australian code AS1170.4 against the seismic design effects
by: AL-OBAIDI, ALI
Published: (2018)

HILAL KHASHAN, Arabs at the crossroads
by: Salloukh, Bassel F.
Published: (2004)

Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium
by: Marek Samec (14727823)
Published: (2019)

Reusable Macroporous Oil Sorbent Films from Plastic Wastes
by: Junaid Saleem (14670322)
Published: (2022)