Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia

Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia

<p dir="ltr">The PML::RARA fusion protein is the hallmark driver of Acute Promyelocytic Leukemia (APL) and disrupts retinoic acid signaling, leading to wide-scale gene expression changes and uncontrolled proliferation of myeloid precursor cells. While known to be recruited to binding...

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Bibliographic Details
Main Author: William Villiers (19482292) (author)
Other Authors: Audrey Kelly (7671395) (author), Xiaohan He (9204173) (author), James Kaufman-Cook (19482295) (author), Abdurrahman Elbasir (9977355) (author), Halima Bensmail (10400) (author), Paul Lavender (7671401) (author), Richard Dillon (9149324) (author), Borbála Mifsud (19482298) (author), Cameron S. Osborne (7244990) (author)
Published: 2023
Subjects:
Biomedical and clinical sciences
Oncology and carcinogenesis
Health sciences
Health services and systems
Information and computing sciences
Machine learning
PML::RARA Fusion Protein
Acute Promyelocytic Leukemia (APL)
Retinoic Acid Signaling
Gene Expression
Myeloid Precursor Cells
Multi-Omics Datasets
Machine Learning
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