Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia

<p dir="ltr">The PML::RARA fusion protein is the hallmark driver of Acute Promyelocytic Leukemia (APL) and disrupts retinoic acid signaling, leading to wide-scale gene expression changes and uncontrolled proliferation of myeloid precursor cells. While known to be recruited to binding...

وصف كامل

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	William Villiers (19482292) (author)
مؤلفون آخرون:	Audrey Kelly (7671395) (author), Xiaohan He (9204173) (author), James Kaufman-Cook (19482295) (author), Abdurrahman Elbasir (9977355) (author), Halima Bensmail (10400) (author), Paul Lavender (7671401) (author), Richard Dillon (9149324) (author), Borbála Mifsud (19482298) (author), Cameron S. Osborne (7244990) (author)
منشور في:	2023
الموضوعات:	Biomedical and clinical sciences Oncology and carcinogenesis Health sciences Health services and systems Information and computing sciences Machine learning PML::RARA Fusion Protein Acute Promyelocytic Leukemia (APL) Retinoic Acid Signaling Gene Expression Myeloid Precursor Cells Multi-Omics Datasets Machine Learning
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia

مواد مشابهة