20-HETE and EETs in Diabetic Nephropathy: A Novel Mechanistic Pathway

20-HETE and EETs in Diabetic Nephropathy: A Novel Mechanistic Pathway

<p>Diabetic nephropathy (DN), a major complication of diabetes, is characterized by hypertrophy, extracellular matrix accumulation, fibrosis and proteinuria leading to loss of renal function. Hypertrophy is a major factor inducing proximal tubular epithelial cells injury. However, the mechanis...

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Bibliographic Details
Main Author: Stephanie Eid (440990) (author)
Other Authors: Rita Maalouf (440991) (author), Ayad A. Jaffa (9717731) (author), Joseph Nassif (440992) (author), Ahmed Hamdy (440993) (author), Awad Rashid (440994) (author), Fuad N. Ziyadeh (11702369) (author), Assaad A. Eid (11256112) (author)
Published: 2013
Subjects:
Biomedical and clinical sciences
Clinical sciences
Medical biochemistry and metabolomics
Diabetes mellitus
Epithelial cells
Glucose
Protein expression
Kidneys
Glucose metabolism
Collagens
Metabolic pathways
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