RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies

RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies

<div><p>Aggregated α-synuclein (αSyn) protein is a core pathological feature of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Both PD and DLB demonstrate the presence of diverse intracellular α-synuclein (αSyn) species, including C-terminally truncated αSyn (C-αSyn), alth...

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Bibliographic Details
Main Author: Ilaria Poggiolini (296742) (author)
Other Authors: Daniel Erskine (3471959) (author), Nishant N. Vaikath (2901785) (author), Janarthanan Ponraj (8535585) (author), Said Mansour (8697699) (author), Christopher M. Morris (741292) (author), Omar M. A. El-Agnaf (8809331) (author)
Published: 2021
Subjects:
Biomedical and clinical sciences
Neurosciences
synucleinopathies
Parkinson’s disease
dementia with Lewy bodies
RT-QuIC
α-synuclein
C-terminally truncated αSyn
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