Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis

Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis

<h3>Background</h3><p dir="ltr">The neutral amino acid transporter <i>SLC7A8</i> (LAT2) has been described as a key regulator of metabolic adaptation. LAT2 mutations in human populations have been linked to the early onset of age‐related hearing loss and catar...

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Main Author: Meritxell Espino‐Guarch (22565774) (author)
Other Authors: Susie Shih Yin Huang (22565777) (author), Clara Vilches (794255) (author), Esther Prat (794256) (author), Rana El Nahas (22565780) (author), Ghalia Missous (22565783) (author), Susanna Bodoy (18810106) (author), Abbirami Sathappan (12862993) (author), Mohammad Ameen Al‐Aghbar (22565786) (author), Clara Mayayo (6795353) (author), Montse Olivé (22565789) (author), Silvia Busquets‐Rius (22565792) (author), David Sebastián (3150915) (author), Antonio Zorzano (35886) (author), Manuel Palacin (35885) (author), Nicholas van Panhuys (14158830) (author), Virginia Nunes (40884) (author)
Published: 2025
Subjects:
Biomedical and clinical sciences
Medical biochemistry and metabolomics
Nutrition and dietetics
ageing
glutamine
LAT2
mTORC1
proteolysis
skeletal muscle
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