Comparison of RTMs of young versus aged mice in vivo.

<p>(A) Snapshots of RTMs from mice of different ages and with different chemical stimulation. Peritoneal macrophages from young mice serve as the control population (N=124), which are compared to peritoneal RTMs from 1 year old mice without (Old, N=70) and with M-CSF stimulation (Old+M-CSF, N=...

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Main Author:	Miriam Schnitzerlein (21446136) (author)
Other Authors:	Eric Greto (21446139) (author), Anja Wegner (10643774) (author), Anna Möller (18076549) (author), Oliver Aust (21446142) (author), Oumaima Ben Brahim (21446145) (author), David B. Blumenthal (11838270) (author), Vasily Zaburdaev (504665) (author), Stefan Uderhardt (21446148) (author)
Published:	2025
Subjects:	Biochemistry Medicine Developmental Biology Space Science Biological Sciences not elsewhere classified physiologically relevant approach monitoring interstitial fluids employed intravital imaging div >< p characteristic morphological changes aged animals displayed interpretable cell size quantify rtm morphodynamics generate dynamic data clearing cellular debris bona fide </ pathological cell states functional tissue age various functional states resident tissue macrophages physiological native state functional states cellular morphodynamics tissue homeostasis cell populations various conditions state conditions functional status dynamic behavior vivo </ vitro </ young counterparts wide range upon challenge shape features qualitative differentiation predominantly within population level naïve morphospace morphodynamical phenotypes inflammatory activation including pro fundamentally different features allowed endosomal dysfunction diverse functions defining human current knowledge behavioral motifs >, enabling
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Comparison of RTMs of young versus aged mice in vivo.

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