Identification of genes involved in GPI biosynthesis as pan-coronavirus host restriction factors.

Identification of genes involved in GPI biosynthesis as pan-coronavirus host restriction factors.

<p>A. Schematic of the genes involved in the GPI biosynthesis pathway. Representative genes involved in the early (<i>PIGA</i>), intermediate (<i>PIGV</i>), and anchoring steps (<i>GPAA1</i>) of the GPI biosynthesis pathway were selected and indicated in red...

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Main Author: Yanlong Ma (3922220) (author)
Other Authors: Fei Feng (427513) (author), Hui Feng (174331) (author), Xue Ma (67782) (author), Ziqiao Wang (6730244) (author), Yutong Han (5447690) (author), Yunkai Zhu (4349152) (author), Yuyan Wang (283747) (author), Zhichao Gao (4261183) (author), Yuyuan Zhang (1275144) (author), Qiang Ding (295913) (author), Jincun Zhao (200043) (author), Rong Zhang (44942) (author)
Published: 2025
Subjects:
Biochemistry
Medicine
Microbiology
Cell Biology
Genetics
Molecular Biology
Physiology
Biotechnology
Evolutionary Biology
Ecology
Immunology
Cancer
Mental Health
Infectious Diseases
Plant Biology
Virology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
various cellular processes
playing essential roles
disrupting spike protein
coronavirus restriction factor
counteract viral infections
coronavirus host factor
mediated membrane fusion
covalently anchor proteins
restrict viral entry
host restriction factors
coronaviruses via regulation
glycosylphosphatidylinositol biosynthesis functions
div >< p
gpi biosynthesis pathway
ly6e </ p
viral entry
host factors
cell membrane
anchored proteins
betacoronavirus </
alphacoronavirus </
gpi biosynthesis
identified ly6e
identified glycosylphosphatidylinositol
plasma membranes
including sars
findings reveal
conducted genome
antiviral activity
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