RTA dephosphorylation mediated by phosphatase PP2A impairs KSHV lytic replication.

<p><b>(A)</b> Phosphatase PP2A agonist Forskolin suppresses the transcription of viral genes. iSLK.RGB cells were induced with doxycycline at different time points as indicated in the absence and presence of phosphatase PP2A agonist Forskolin (40 μM). RNA was extracted from cells t...

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Autor principal:	Lei Bai (631944) (author)
Otros Autores:	Lianghui Dong (7908431) (author), Jiazhen Dong (595963) (author), Xiaowei Liang (4721025) (author), Jiangwei Peng (21524781) (author), Yuncai Chen (7541564) (author), Xiaoyi Sun (2323519) (author), Yuting Chen (151583) (author), Xintong Li (3110796) (author), Hua Cai (15034) (author), Jing Huang (41604) (author), Zixu Cao (22772675) (author), Ke Lan (232754) (author)
Publicado:	2025
Materias:	Biochemistry Microbiology Cell Biology Molecular Biology Evolutionary Biology Cancer Science Policy Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified provide new insights new binding partner human &# 947 host antiviral mechanism scaffold protein ppp2r1a promote ppp2r1a degradation initiating lytic replication kshv progeny virions viral lytic replication lytic replication ppp2r1a overexpression encoded replication viral latency transcription factor transcription activity transcription activator taken together proteasome pathway pharmacological agonist next demonstrated life cycle fully elucidated extensive studies central role
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RTA dephosphorylation mediated by phosphatase PP2A impairs KSHV lytic replication.

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