Enantioselective Synthesis of Chiral Acyclic Nitriles Containing α‑All-Carbon Quaternary Stereocenters via Synergistic Palladium and Phase-Transfer Catalysis

Herein, we present a practical strategy for the asymmetric synthesis of chiral acyclic nitriles featuring α-all-carbon quaternary stereocenters, utilizing synergistic palladium and phase-transfer catalysis from allyl 2-cyanoacetates under mild conditions. This approach offers an efficient and reliab...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Cheng Guo (573654) (author)
مؤلفون آخرون:	Yufei Dong (8997452) (author), Yiyang Wang (291591) (author), Xuan Du (3692404) (author), Runxia Ma (20418152) (author), Choon-Hong Tan (216853) (author), Xinjun Luan (1614730) (author), Jingyun Ren (1677289) (author)
منشور في:	2024
الموضوعات:	Biochemistry Medicine Microbiology Genetics Molecular Biology Evolutionary Biology Virology Computational Biology Space Science Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified carbon quaternary stereocenters utilizing synergistic palladium transfer catalysis herein transfer catalysis intramolecular palladium transfer catalysts tertiary α synthetic utility subsequent transformation situ generation scale synthesis practical strategy pairing interactions mild conditions enantioselective synthesis cyano carbanions asymmetric synthesis approach offers allyl 2
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Enantioselective Synthesis of Chiral Acyclic Nitriles Containing α‑All-Carbon Quaternary Stereocenters via Synergistic Palladium and Phase-Transfer Catalysis

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