Developing an Arene Binuclear Ruthenium(II) Complex to Induce Ferroptosis and Activate the cGAS-STING Pathway: Targeted Inhibiting Growth and Metastasis of Triple Negative Breast Cancer

To effectively inhibit the growth and metastasis of triple-negative breast cancer (TNBC), we developed a high-efficiency and low-toxicity arene ruthenium (Ru) complex based on apoferritin (AFt). To achieve this, we optimized a series of Ru(II) 1,10-phenanthroline-2,9-diformaldehyde thiosemicarbazone...

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Bibliographic Details
Main Author:	Gang Xu (219455) (author)
Other Authors:	Qiongyue Liang (12453129) (author), Lijuan Gao (5093777) (author), Shihang Xu (16510992) (author), Weicong Luo (10464160) (author), Qiuming Wu (19928931) (author), Jingyuan Li (53885) (author), Zhenlei Zhang (2585365) (author), Hong Liang (116853) (author), Feng Yang (132135) (author)
Published:	2024
Subjects:	Biochemistry Medicine Microbiology Cell Biology Pharmacology Developmental Biology Cancer Plant Biology Space Science Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified toxicity arene ruthenium negative breast cancer diformaldehyde thiosemicarbazone complexes arene binuclear ruthenium targeted inhibiting growth arene binuclear ru aft nps improved aft nanoparticle aft ). tumor cells tnbc ), targeting abilities sting pathway significant cytotoxicity side effects mediated ferroptosis induce ferroptosis effectively inhibit delivery system
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Developing an Arene Binuclear Ruthenium(II) Complex to Induce Ferroptosis and Activate the cGAS-STING Pathway: Targeted Inhibiting Growth and Metastasis of Triple Negative Breast Cancer

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