Regulatory mechanisms of embryo development revealed by the “dark genes” in the human embryonic stem cell (hESC)-to-definitive endoderm cell (DEC) process.

<p>(A) Gene set enrichment analysis of “dark genes”. (B) Enrichment analysis of Kyoto Encyclopedia of Genes and Genomes pathways for the “dark genes” in the hESC-to-DEC process. (C) The outer ring’s left segment delineates the dynamic network biomarkers (DNBs) recognized using the DNFE method,...

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Bibliographic Details
Main Author:	Xueqing Peng (10678527) (author)
Other Authors:	Rui Qiao (458542) (author), Peiluan Li (6156950) (author), Luonan Chen (21547) (author)
Published:	2025
Subjects:	Biophysics Cell Biology Genetics Molecular Biology Developmental Biology Cancer Infectious Diseases Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Physical Sciences not elsewhere classified Information Systems not elsewhere classified xlink "> typically outperforms existing methods identified &# 8220 dynamic biological processes delay disastrous outcomes six real datasets one stable state detecting tipping points dynamic network biomarkers method &# 8217 including three single identifying critical states critical state tipping point cell datasets driving network directed network usually overlooked scale data sample data numerical simulations implemented based dimensional small cell rna cell data bulk data blood dataset
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Regulatory mechanisms of embryo development revealed by the “dark genes” in the human embryonic stem cell (hESC)-to-definitive endoderm cell (DEC) process.

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