Regulatory mechanisms of embryo development revealed by the “dark genes” in the human embryonic stem cell (hESC)-to-definitive endoderm cell (DEC) process.
<p>(A) Gene set enrichment analysis of “dark genes”. (B) Enrichment analysis of Kyoto Encyclopedia of Genes and Genomes pathways for the “dark genes” in the hESC-to-DEC process. (C) The outer ring’s left segment delineates the dynamic network biomarkers (DNBs) recognized using the DNFE method,...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| منشور في: |
2025
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| الملخص: | <p>(A) Gene set enrichment analysis of “dark genes”. (B) Enrichment analysis of Kyoto Encyclopedia of Genes and Genomes pathways for the “dark genes” in the hESC-to-DEC process. (C) The outer ring’s left segment delineates the dynamic network biomarkers (DNBs) recognized using the DNFE method, highlighting their presence in the differentiation process. The outer ring’s right segment corresponds to the array of biological processes in which these DNBs participate, showcasing their multifaceted roles. Within the inner ring, the color-coding and link thickness are utilized to represent the diversity of enriched pathways and the statistical significance of gene functions, respectively. (D) The “dark genes” and their first-order differentially expressed gene neighbors are further examined to uncover the intrinsic signaling mechanisms.</p> |
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