Table 1_Effect of preoperative intranasal dexmedetomidine versus placebo on intraoperative shivering in parturients undergoing cesarean section: a randomized controlled trial.docx
Background<p>Shivering during cesarean section under epidural anesthesia is common and may negatively affect maternal comfort, surgical conditions, and physiological stability. This single-blinded, randomized controlled trial evaluated whether preoperative intranasal dexmedetomidine reduces th...
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2025
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| _version_ | 1849927636225097728 |
|---|---|
| author | Guolin Xu (2963358) |
| author2 | Zhuhong Tian (22679180) Yong Ding (108968) Jingjing Ma (419752) Rui Li (4631) |
| author2_role | author author author author |
| author_facet | Guolin Xu (2963358) Zhuhong Tian (22679180) Yong Ding (108968) Jingjing Ma (419752) Rui Li (4631) |
| author_role | author |
| dc.creator.none.fl_str_mv | Guolin Xu (2963358) Zhuhong Tian (22679180) Yong Ding (108968) Jingjing Ma (419752) Rui Li (4631) |
| dc.date.none.fl_str_mv | 2025-11-25T06:16:16Z |
| dc.identifier.none.fl_str_mv | 10.3389/fphar.2025.1661683.s002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Table_1_Effect_of_preoperative_intranasal_dexmedetomidine_versus_placebo_on_intraoperative_shivering_in_parturients_undergoing_cesarean_section_a_randomized_controlled_trial_docx/30703844 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Pharmacology cesarean section epidural anesthesia shivering dexmedetomidine intranasal administration |
| dc.title.none.fl_str_mv | Table 1_Effect of preoperative intranasal dexmedetomidine versus placebo on intraoperative shivering in parturients undergoing cesarean section: a randomized controlled trial.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | Background<p>Shivering during cesarean section under epidural anesthesia is common and may negatively affect maternal comfort, surgical conditions, and physiological stability. This single-blinded, randomized controlled trial evaluated whether preoperative intranasal dexmedetomidine reduces the incidence of shivering in parturients undergoing cesarean delivery.</p>Methods<p>A total of 170 parturients scheduled for elective cesarean section under continuous epidural anesthesia were randomized into a dexmedetomidine group (group DEX) or control group (group CON). The group DEX received 1 μg/kg intranasal dexmedetomidine (diluted to 1 mL), and the group CON received 1 mL intranasal normal saline approximately 30 min before anesthesia. The primary outcomes were the incidence, severity, frequency, and duration of shivering. Neonatal safety was evaluated using Apgar scores at 1 and 5 min after delivery.</p>Results<p>A total of 160 patients completed the study. The incidence, frequency, severity, and duration of intraoperative shivering reactions were significantly lower in the group DEX than in the group CON (P < 0.01). Compared with those in the group CON, there were significantly more patients with level 2 sedation in the group DEX (P < 0.01). There were no significant differences in maternal hypotension, bradycardia, or nausea and vomiting events between the two groups (P > 0.01). There were no significant differences in Apgar scores between the two groups (P > 0.05).</p>Conclusion<p>Preoperative intranasal administration of dexmedetomidine effectively prevents intraoperative shivering in parturients undergoing cesarean section.</p>Clinical Trial Registration<p>https://www.chictr.org.cn identifier: ChiCTR2400079811.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_0289ef209fe7efbea8608663073cf7d4 |
| identifier_str_mv | 10.3389/fphar.2025.1661683.s002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30703844 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Table 1_Effect of preoperative intranasal dexmedetomidine versus placebo on intraoperative shivering in parturients undergoing cesarean section: a randomized controlled trial.docxGuolin Xu (2963358)Zhuhong Tian (22679180)Yong Ding (108968)Jingjing Ma (419752)Rui Li (4631)Pharmacologycesarean sectionepidural anesthesiashiveringdexmedetomidineintranasal administrationBackground<p>Shivering during cesarean section under epidural anesthesia is common and may negatively affect maternal comfort, surgical conditions, and physiological stability. This single-blinded, randomized controlled trial evaluated whether preoperative intranasal dexmedetomidine reduces the incidence of shivering in parturients undergoing cesarean delivery.</p>Methods<p>A total of 170 parturients scheduled for elective cesarean section under continuous epidural anesthesia were randomized into a dexmedetomidine group (group DEX) or control group (group CON). The group DEX received 1 μg/kg intranasal dexmedetomidine (diluted to 1 mL), and the group CON received 1 mL intranasal normal saline approximately 30 min before anesthesia. The primary outcomes were the incidence, severity, frequency, and duration of shivering. Neonatal safety was evaluated using Apgar scores at 1 and 5 min after delivery.</p>Results<p>A total of 160 patients completed the study. The incidence, frequency, severity, and duration of intraoperative shivering reactions were significantly lower in the group DEX than in the group CON (P < 0.01). Compared with those in the group CON, there were significantly more patients with level 2 sedation in the group DEX (P < 0.01). There were no significant differences in maternal hypotension, bradycardia, or nausea and vomiting events between the two groups (P > 0.01). There were no significant differences in Apgar scores between the two groups (P > 0.05).</p>Conclusion<p>Preoperative intranasal administration of dexmedetomidine effectively prevents intraoperative shivering in parturients undergoing cesarean section.</p>Clinical Trial Registration<p>https://www.chictr.org.cn identifier: ChiCTR2400079811.</p>2025-11-25T06:16:16ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fphar.2025.1661683.s002https://figshare.com/articles/dataset/Table_1_Effect_of_preoperative_intranasal_dexmedetomidine_versus_placebo_on_intraoperative_shivering_in_parturients_undergoing_cesarean_section_a_randomized_controlled_trial_docx/30703844CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307038442025-11-25T06:16:16Z |
| spellingShingle | Table 1_Effect of preoperative intranasal dexmedetomidine versus placebo on intraoperative shivering in parturients undergoing cesarean section: a randomized controlled trial.docx Guolin Xu (2963358) Pharmacology cesarean section epidural anesthesia shivering dexmedetomidine intranasal administration |
| status_str | publishedVersion |
| title | Table 1_Effect of preoperative intranasal dexmedetomidine versus placebo on intraoperative shivering in parturients undergoing cesarean section: a randomized controlled trial.docx |
| title_full | Table 1_Effect of preoperative intranasal dexmedetomidine versus placebo on intraoperative shivering in parturients undergoing cesarean section: a randomized controlled trial.docx |
| title_fullStr | Table 1_Effect of preoperative intranasal dexmedetomidine versus placebo on intraoperative shivering in parturients undergoing cesarean section: a randomized controlled trial.docx |
| title_full_unstemmed | Table 1_Effect of preoperative intranasal dexmedetomidine versus placebo on intraoperative shivering in parturients undergoing cesarean section: a randomized controlled trial.docx |
| title_short | Table 1_Effect of preoperative intranasal dexmedetomidine versus placebo on intraoperative shivering in parturients undergoing cesarean section: a randomized controlled trial.docx |
| title_sort | Table 1_Effect of preoperative intranasal dexmedetomidine versus placebo on intraoperative shivering in parturients undergoing cesarean section: a randomized controlled trial.docx |
| topic | Pharmacology cesarean section epidural anesthesia shivering dexmedetomidine intranasal administration |