The nuclease activities of MRN complex participate in regulating the formation of HBV cccDNA.

<p>HepG2-NTCP-K7 cells were treated with Mirin (A-G) or PFM01 (H-N) as shown by the experimental layout (A and H). Samples were harvested at 5 days post infection (dpi) to detect. (B and I) The effects of Mirin or PFM01 on cell viabilities were detected by CCK-8 assay. (C and J) HBeAg in the c...

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Bibliographic Details
Main Author:	Kaitao Zhao (3617825) (author)
Other Authors:	Jingjing Wang (140791) (author), Zichen Wang (2473054) (author), Mengfei Wang (4899196) (author), Chen Li (54018) (author), Zaichao Xu (15877593) (author), Qiong Zhan (655660) (author), Fangteng Guo (15232739) (author), Xiaoming Cheng (556761) (author), Yuchen Xia (9287840) (author)
Published:	2025
Subjects:	Biochemistry Medicine Microbiology Cell Biology Molecular Biology Pharmacology Cancer Infectious Diseases Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified varies host factors chromatin immunoprecipitation assay identified host factors findings provide insights div >< p establish chronic infection cccdna without affecting rcdna repair system rad50 &# 8211 minichromosome </ p mrn complex inhibitor mrn complex inhibited mrn complex cooperates hbv infection showed regulating cccdna formation mrn complex vitro </ identified co findings indicate mrn knockdown hbv infection including cccdna hbv cccdna cccdna formation well characterized viral replication transcriptional activity took advantage stably knockdown significantly increase results revealed reconstitution reversed precipitated proteins potential factor mass spectrometry major obstacle liver cancer hbv dna exonuclease activity detailed mechanisms dependent activation curative treatment chk1 pathway antiviral treatments
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The nuclease activities of MRN complex participate in regulating the formation of HBV cccDNA.

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