A controlled comparative study of the effects of methotrexate and pharmacogenetic factors on arterial blood pressure and arterial stiffness in patients with rheumatoid arthritis

A controlled comparative study of the effects of methotrexate and pharmacogenetic factors on arterial blood pressure and arterial stiffness in patients with rheumatoid arthritis

<p>Observational studies have shown that methotrexate, a conventional synthetic disease-modifying antirheumatic drug (csDMARD), is associated with lower arterial blood pressure (BP) and may reduce cardiovascular risk in rheumatoid arthritis (RA). However, it remains unclear whether a cause-and...

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Bibliographic Details
Main Author: Arduino A. Mangoni (10931181) (author)
Other Authors: Michael D. Wiese (8828210) (author), Richard J. Woodman (8830580) (author), Salvatore Sotgia (505440) (author), Angelo Zinellu (276951) (author), Ciriaco Carru (276952) (author), Julie-Ann Hulin (363244) (author), E. Michael Shanahan (9512325) (author), Sara Tommasi (21842416) (author)
Published: 2025
Subjects:
Medicine
Cell Biology
Physiology
Biotechnology
Ecology
Immunology
Science Policy
Biological Sciences not elsewhere classified
Methotrexate
inflammation
rheumatoid arthritis
drug repositioning
atherosclerosis
cardiovascular disease
blood pressure
pharmacogenetics
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