CYP46A1 and 24-OHC levels in CYP46A1 knockout mice.

CYP46A1 and 24-OHC levels in CYP46A1 knockout mice.

<p><b>(A)</b> Immunoblot analysis of CYP46A1 in the striatum of wild-type (WT), CYP46A1<sup>+/−</sup>, and CYP46A1<sup>−/−</sup> mice (<i>n</i> = 6 independent experiments). <b>(B)</b> Plasma 24-OHC levels detected by LC-MS (<i>...

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Main Author: Lijun Dai (2407099) (author)
Other Authors: Jiannan Wang (154792) (author), Lanxia Meng (564023) (author), Xingyu Zhang (408987) (author), Tingting Xiao (838381) (author), Min Deng (114029) (author), Guiqin Chen (5955809) (author), Jing Xiong (218613) (author), Wei Ke (158476) (author), Zhengyuan Hong (20746042) (author), Lihong Bu (443666) (author), Zhentao Zhang (218622) (author)
Published: 2025
Subjects:
Biochemistry
Cell Biology
Neuroscience
Science Policy
Biological Sciences not elsewhere classified
whereas genetic removal
parkinson &# 8217
mitochondrial dysfunction induced
activation gene 3
nigrostriatal dopaminergic degeneration
neurodegenerative disease characterized
xbp1 &# 8211
ohc promote neurotoxicity
disease </ p
dopaminergic neurons
substantia nigra
strategies aimed
specific oxysterol
ohc exacerbates
ohc enhances
ohc axis
ohc ),
mouse model
modifying therapies
lewy bodies
intracerebral injection
cerebrospinal fluid
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