AlphaFold predicted interactions of mutant Mcm3’s NLS with Kap60.

AlphaFold predicted interactions of mutant Mcm3’s NLS with Kap60.

<p>A) AlphaFold predicted interaction of Kap60 and the lysine at position 2 (P2, colored in white) of Mcm3’s NLS (<sup>764</sup>KSPKKRQRV<sup>772</sup>), or the SV40-NLS substitution construct (<sup>764</sup>KSPKKKRKV<sup>772</sup>). B) AlphaFold...

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Bibliographic Details
Main Author: Ziyi Wang (1956610) (author)
Other Authors: Yun Jing Zhang (20592158) (author), Qian-yi Zhang (12867706) (author), Kate Bilsborrow (20592161) (author), Matthew Leslie (5010068) (author), Raymond T. Suhandynata (2805466) (author), Huilin Zhou (374813) (author)
Published: 2025
Subjects:
Medicine
Cell Biology
Genetics
Molecular Biology
Evolutionary Biology
Cancer
Virology
Biological Sciences not elsewhere classified
replicative dna helicase
defective chromatin loading
basic residues within
basic amino acids
single consensus sequence
xlink "> proteins
poor cell growth
nuclear localization sequences
universally conserved sequence
analyzing monopartite nlss
mcm3 </ p
sequence specificity
cell nucleus
nuclear transport
nuclear import
sv40 large
results provide
precise positioning
mcm complex
importin proteins
identifying nlss
guided framework
despite lacking
conserved nls
challenging due
alphafold 3
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