Paradoxical activation (PA) of the RAS pathway and its analysis with a series of analytical mathematical models.

<p>Paradoxical activation (PA) of the RAS pathway and its analysis with a series of analytical mathematical models.</p>

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Бібліографічні деталі
Автор:	Gaurav Mendiratta (21956986) (author)
Інші автори:	Kodye Abbott (21956989) (author), Yao-Cheng Li (11300) (author), Jingting Yu (6652841) (author), Peter Carlip (21956992) (author), Melinda Tong (21956995) (author), Jianfeng Huang (570138) (author), Maxim N. Shokhirev (2391904) (author), Thomas McFall (15008405) (author), Geoffrey M. Wahl (8450322) (author), Edward C. Stites (21956998) (author)
Опубліковано:	2025
Предмети:	Biophysics Biochemistry Cell Biology Molecular Biology Biotechnology Immunology Developmental Biology Cancer Hematology Infectious Diseases Biological Sciences not elsewhere classified two different approaches normally show little based insights experimentally experimental data analysis raf signal regulation active raf dimer suggest increased 14 mathematically show 14 3 protein stabilization raf inhibitors plays raf inhibitors ). find amplifies pa evolved resistance assays 3 proteins may modulate raf ca raf inhibitors 3 proteins analysis suggests raf dimerization modulating raf 3 expression work supports reduce pa recently demonstrated potentiate pa mathematical modeling inducing pa forced increases conformational autoinhibition autoinhibited form
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