Impact of RNA modification gene deletions on fitness during growth in sub-MIC tobramycin.

A. Inosine frequency on tRNAArg detected in RNA-seq performed on V. cholerae without and with subinhibitory concentration of tobramycin (TOB, 0.4 µg/ml). For statistical analysis, student’s t-test was used. * means p < 0.05. B. In vitro&...

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Hlavní autor:	Léo Hardy (22538036) (author)
Další autoři:	Virginie Marchand (219509) (author), Valérie Bourguignon (14503342) (author), Quentin Thuillier (22538039) (author), Cathy Dias (22538042) (author), Evelyne Krin (252784) (author), Louna Fruchard (22538045) (author), Dan Bar Yaacov (11965433) (author), Didier Mazel (158958) (author), Yuri Motorin (773232) (author), Zeynep Baharoglu (88371) (author)
Vydáno:	2025
Témata:	Biophysics Biochemistry Microbiology Genetics Molecular Biology Sociology Space Science Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified subinhibitory antibiotic stress first experimentally validated ensuring precise decoding div >< p trna epitranscriptomic landscape functional trmk enzyme based sequencing methods vibrio cholerae </ comprehensive modification landscape rna modification enzymes cholerae </ functional impact cognate enzymes coli </ trna modifications work provides translation regulation transfer rnas standard conditions specific features specific differences rna species rna modifications protein synthesis positive bacteria occurs independently largely restricted human pathogen genetic code future research evaluated fitness diversely modified delivering aminoacids deletion strains comparing wild comparative analysis biological significance biological importance anticodon stem
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Impact of RNA modification gene deletions on fitness during growth in sub-MIC tobramycin.

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