Schematic illustration of potential pathways for macrophages to traffic out of the CNS.

<p>Macrophages and other immune cells may exit the CNS via several distinct anatomical routes: (i) Dorsal and basal dural lymphatics, which drain cerebrospinal fluid (CSF) and associated immune cells to peripheral lymph nodes; (ii) Olfactory bulb–cribriform plate axis, facilitating migration t...

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Detalhes bibliográficos
Autor principal:	Zoey K. Wallis (17725175) (author)
Outros Autores:	Cecily C. Midkiff (11083425) (author), Miaoyun Zhao (18996267) (author), Patrick Autissier (93068) (author), Soon Ok Kim (22756434) (author), Addison Q. Amadeck (22756437) (author), Yiwei Wang (403386) (author), Maia Jakubowski (22756440) (author), Tricia H. Burdo (9592101) (author), Andrew D. Miller (328799) (author), Qingsheng Li (515132) (author), Xavier Alvarez (33185) (author), Robert V. Blair (11722847) (author), Kenneth C. Williams (11527354) (author)
Publicado em:	2025
Assuntos:	Medicine Microbiology Neuroscience Immunology Infectious Diseases Plant Biology Virology Environmental Sciences not elsewhere classified sup >+</ sup simian immunodeficiency virus peripheral sites including myeloid cell egress human immunodeficiency virus dorsal root ganglia central nervous system track macrophage turnover observed higher numbers labeled macrophages within div >< p cns viral reservoirs art reduces trafficking cns </ p perivascular macrophage reservoir following art interruption meningeal macrophages persisted meningeal macrophages increased choroid plexus macrophages art eliminated siv scattered viral rna choroid plexus macrophage traffic art interruption meningeal macrophages trafficking diminished scattered siv low numbers treatment interruption perivascular macrophages macrophages trafficked infected macrophages viral infection art treatment art decreased preferentially taken lesser extent infected macaques findings support enabling us c .) assess establishment antiretroviral therapy administered intracisternal 30 days
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Schematic illustration of potential pathways for macrophages to traffic out of the CNS.

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