Effect of asymmetries on tristable phase portrait with a highly attractive non-differentiated state.

Effect of asymmetries on tristable phase portrait with a highly attractive non-differentiated state.

<p>Shift of steady states when asymmetry favours state <b><i>A</i></b> (column (A), ) or state <b><i>B</i></b> (column (C), ) compared to the symmetric case (column (B), ). Asymmetry applied through , corresponds to rows (1) and (2) respectively....

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Bibliographic Details
Main Author:	Corentin Robert (20902823) (author)
Other Authors:	Francisco Prista von Bonhorst (20902826) (author), Geneviève Dupont (330270) (author), Didier Gonze (69567) (author), Yannick De Decker (12572813) (author)
Published:	2025
Subjects:	Biophysics Cell Biology Genetics Molecular Biology Immunology Developmental Biology Hematology Computational Biology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified toggle switch model systematic analysis revealed study thoroughly explored includes reproducible proportions grn components controlling gene regulatory networks specification process marked initial expression levels differentiated cell fates div >< p replicate observed robustness grn ’ competing gene b >< differentiated states differentiated cells various contexts system escape stochastic noise signalling cascades primitive endoderm prevents cells new identity mathematical models key genes extended version epiblast cells common progenitors cell differentiation blastocyst formation biochemical reactions activation loops ></ b
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