Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain

Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain

Activation of cytokine and growth factor receptors by ligands triggers crucial cellular responses in various physiological processes. However, our understanding of their structural basis remains incomplete due to the limited information on the active ligand–receptor complex structure. Their structur...

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Bibliografische gegevens
Hoofdauteur:	Neval Yilmaz (1544557) (author)
Andere auteurs:	Hiroki Tanino (22686882) (author), Shun Sakuraba (1368381) (author), Romain Amyot (9657017) (author), Holger Flechsig (213426) (author), Atsushi Matsumoto (593817) (author), Hidetoshi Kono (19475) (author), Leonardo Puppulin (11688279) (author), Mikihiro Shibata (2075461) (author), Hiroshi Aoyama (832169) (author), Tsuyoshi Inoue (559318) (author), Kunio Matsumoto (412408) (author), Katsuya Sakai (11688282) (author)
Gepubliceerd in:	2025
Onderwerpen:	Biophysics Biochemistry Cell Biology Molecular Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified molecular dynamics simulations luciferase complementary assay hepatocyte growth factor growth factor receptors electron microscopy experiments chemically fixing prior also conducted split various physiological processes proximal domain activation proximal region sema domain ipt4 domain distal domain physiological hgf structural features resolution characterization protein level living cells limited information induced dimerization active complex
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Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain
door: Neval Yilmaz (1544557)
Gepubliceerd in: (2025)

Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain
door: Neval Yilmaz (1544557)
Gepubliceerd in: (2025)

Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain
door: Neval Yilmaz (1544557)
Gepubliceerd in: (2025)

Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain
door: Neval Yilmaz (1544557)
Gepubliceerd in: (2025)

YajC co-expression does not alter the membrane localization or abundance of LdrA-FLAG.
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YajC recognition of LdrA requires both transmembrane and cytoplasmic domains.
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YajC Specifically Neutralizes Ldr Family Toxins.
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Overexpression of YajC is sufficient to alleviate LdrA-induced toxicity.
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Genetic Screen Identifies YajC as an LdrA-Neutralizing Factor.
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LdrA expression causes transient growth arrest and the FLAG tag does not affect its toxicity.
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YajC has no effect on unrelated TA toxins.
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