$Schematic representation of Ferrozine-based iron quantification of PV and cytoplasmic fraction and transcriptomic landscape of LD-S and LD-R-infected-MФs at 4 hrs and 24 hrs pi as compared to uninfected-MФs.$

Schematic representation of Ferrozine-based iron quantification of PV and cytoplasmic fraction and transcriptomic landscape of LD-S and LD-R-infected-MФs at 4 hrs and 24 hrs pi as compared to uninfected-MФs.

<p>(A.i.) Scheme showing PV extraction from LD-S and LD-R infected-MФs at 4 hrs and 24 hrs pi ensued by quantification of iron following Ferrozine-based colorimetric assay. <b>(A.ii.)</b> Heatmap showing iron concentration in cytoplasmic-fraction and PV-fraction of LD-S and LD-R in...

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Main Author:	Souradeepa Ghosh (14276657) (author)
Other Authors:	Krishna Vamshi Chigicherla (20649145) (author), Shirin Dasgupta (20649148) (author), Yasuyuki Goto (22965) (author), Budhaditya Mukherjee (106862) (author)
Published:	2025
Subjects:	Biochemistry Medicine Microbiology Cell Biology Biotechnology Evolutionary Biology Ecology Inorganic Chemistry Hematology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified unresponsiveness points towards treating visceral leishmaniasis sustaining heightened levels selectively reshuffling macrophage recent clinical isolates leishmania donovani </ inherent metabolic shift even though anti div >< p surface iron exporter subsequent iron insufficiency higher iron utilization triggering oxidative outburst gained increased potential withstand elevated ros elevated ros levels pv thereby gaining pentavalent antimonials relies surplus iron iron within oxidative stress increased erythrophagocytosis two proteases survival edge surprising strategy study highlights sensitive counterparts parasitophorous vacuoles leishmanial activity intracellular pathogens infected macrophages genetic adaptation evolutionary persistence complex interplay cd47 surveillance aggressive proliferation
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Schematic representation of Ferrozine-based iron quantification of PV and cytoplasmic fraction and transcriptomic landscape of LD-S and LD-R-infected-MФs at 4 hrs and 24 hrs pi as compared to uninfected-MФs.

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